Simulation Notes Europe, Volume 23(2), August 2013

Modelling Metabolic Pathways Involved in the Pathogenesis of Non-Alcoholic Fatty Liver Disease

Simulation Notes Europe SNE 23(2), 2013, 71-76
DOI: 10.11128/


Non-alcoholic fatty liver disease (NAFLD) is a poorly understood complex disorder that occurs at a high frequency in Western populations with unhealthy dietary and lifestyle habits. Systems biology tools may provide further insight into the multidimensional nature of NAFLD. A dynamic semiquantitative model of the metabolic and signaling pathways suggested to be important in the pathogenesis of NAFLD has been generated using an object-oriented library of components based on differential equations. Initial model validation procedures to draw a comparison between experimental data and model simulations has suggested a close correlation between experimental models and the in silico network. Furthermore, the stiffness of multisubstrate reactions indicates the presence of a balance between pathway fluxes within the network. The model aims to identify novel mechanisms of NAFLD pathogenesis and regulatory components, thus providing a basis for experimental hypotheses.